Jessica Pegula said her first-round exit earlier on Tuesday was her “worst result of the year” as she was beaten by a player ranked 113 places below her.
The 31-year-old had heavy strapping on her right knee but said that did not bother her as she was dismantled in just 58 minutes on Court Two by Cocciaretto.
“This is definitely probably the worst result I’ve had all year,” the American said.
“I’ve been winning lots of matches. It’s just all about it having to come together for two weeks. Sometimes it doesn’t quite all align when you need it to.”
Pegula has only once gone beyond the quarter-final stage of a major – at last year’s US Open where she lost to Aryna Sabalenka in the final – and has gone out before the last eight in all three Grand Slam tournaments since.
This marks her worst performance at a major since the 2020 French Open.
Less than three hours later she was followed out of the door by Chinese fifth seed Zheng after a grass-court lesson from doubles champion Siniakova.
Siniakova, who has won the Wimbledon women’s doubles title three times, showed her grass-court pedigree to ensure Zheng’s challenge ended at the first hurdle for the third year in a row. It was the Czech who also knocked her out at the same stage two years ago.
Polish eighth seed Iga Swiatek advanced with a comprehensive 7-5 6-1 victory over Russia’s Polina Kudermetova.
Teenager Mirra Andreeva was also a 6-3 6-3 winner against Egypt’s Mayar Sherif while 2022 Wimbledon champion Elena Rybakina cruised through with a 6-2 6-1 victory over Armenia’s Elina Avanesyan.
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